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PB-22 and 5F-PB-22 have been the primary synthetic cannabinoids to incorporate a quinoline substructure and an ester linkage. These compounds are imagined to have already been synthesized While using the intention of making a synthetic cannabinoid prodrug, which could improve absorption and confound detection. Ester bonds are effortlessly biodegradable by means of spontaneous or endogenous, nonspecific esterase hydrolysis, that has been frequently used in medicinal chemistry for making ester prodrugs.
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